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KMID : 0606920090170030249
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Biomolecules & Therapeutics
2009 Volume.17 No. 3 p.249 ~ p.255
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Forsythiaside, a Constituent of the Fruits of Forsythia suspense, Ameliorates Scopolamine-Induced Memory Impairment in Mice
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Kim Sun-Ho
Lee Seung-Ho
Ryu Jong-Hoon
Lee Jong-Koo
Kim Dong-Hyun
Ko Kwang-Ho
Choi Ji-Joung
Lee Choong-Ho
Park Se-Jin
Jung Won-Yong
Park Dong-Hyun
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Abstract
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Forsythiaside is a polyphenolic constituent of the fruits of Forsythia suspense Vahl which are widely used as anti-inflammatory herbal raw materials in traditional Chinese medicine. In the present study, the authors assessed the effects of forsythiaside on learning and memory impairments induced by scopolamine using a passive avoidance and the Morris water maze tests in mice. Drug-induced amnesia was induced by scopolamine treatment (1 mg/kg, i.p.). Forsythiaside (10 mg/kg, p.o) administration significantly prevented scopolamine-induced step-through latency reduction in the passive avoidance test and scopolamine-induced increased escape latency in the Morris water maze test (p＜0.05). Moreover, in an ex-vivo study, forsythiaside treatment (10 mg/kg, p.o) significantly reduced the increase of thiobarbituric acid reactive substance levels induced by scopolamine (p＜0.05). Taken together, the present study suggests that forsythiaside could be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by its antioxidative properties.
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KEYWORD
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Forsythiaside, Memory, Passive avoidance task, Morris water maze task, Antioxidant
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